For those with sensitive skin, finding effective yet gentle skincare products can be challenging. The emergence of polyhydroxy acids (PHAs) offers a promising solution for individuals who previously avoided chemical exfoliation due to irritation concerns.

Polyhydroxy acids (PHAs) represent a class of chemical exfoliants known for their mild properties. These compounds provide similar benefits to their more familiar counterparts—alpha hydroxy acids (AHAs) and beta hydroxy acids (BHAs)—but with significantly reduced irritation potential.

Common PHA variants include:

• Gluconolactone (the primary ingredient in AVEENO® Skin Renewal products)
• Galactose
• Lactobionic acid

PHAs offer several advantages for delicate complexions:

• Gentle exfoliation without significant irritation
• Enhanced skin barrier function
• Additional moisturizing properties absent in AHAs
• Promotion of smoother, more radiant skin through cellular renewal

The molecular structure of PHAs differs importantly from other hydroxy acids. Their larger size prevents deep skin penetration, resulting in milder effects. While combination products containing PHAs, AHAs, and BHAs may benefit some users, those with sensitive skin often achieve better results with PHA-only formulations.

PHA-infused products are available in various forms, including cleansers, moisturizers, and toners. When introducing these products:

• Conduct preliminary patch testing
• Begin with alternate-day application
• Gradually increase frequency as tolerance develops
• Follow exfoliation with hydrating serums and barrier-supporting moisturizers

For optimal results, pair PHA products with complementary ingredients like glycerin, hyaluronic acid, and ceramides. Avoid simultaneous use with pH-sensitive actives such as vitamin C—consider morning application for vitamin C products and evening use for PHA exfoliants.

Gluconolactone, a naturally occurring PHA derivative, serves as the active ingredient in the AVEENO® Skin Renewal line. This compound works synergistically with colloidal oatmeal to support skin's microbiome while promoting gentle exfoliation.

Common usage frequencies vary by product type—while some PHA formulations (like cleansers and moisturizers) may suit daily use, others (such as intensive treatments) typically recommend weekly application.